Agree
Thanks
Paediatric Gastroenterologist
Yes. The small bowel biopsy is the gold standard to diagnose coeliac disease.
However in paediatric patients, the ESPGHAN guidelines stated that if tTG IgA (one of the coeliac serology) is more than 10 times the upper limit of normal, potentially coeliac disease could be diagnosed without biopsy. This need to be supported by a second blood test, HLA test (genetic testing) and frequent followup showing improvement of coeliac serology after starting gluten free diet. This European guideline has not been adopted in Australia.
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