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Eye drops are generally very safe and have relatively low rates of side effects.
Some of the more common side effects relate to ocular surface disease , which can cause dry red eyes with grittiness. There could be allergies, red and/or sore eyes, dry eyes.
Possible side effects include those specific to the agent being used (e.g. long eye lashes from prostaglandins like latanoprost, bitter taste from carbonic anhydrase inhibitors like dorzolamide, decreased blood pressure from alpha-agonists like brimonidine, wheezing from beta-blockers like timolol) and those related to the preservative, especially if that preservative is benzalkonium chloride. It would be good to discuss any specific problems with the treating ophthalmologist.
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