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  • Q&A with Australian Health Practitioners

    Why can't I get off Prednisolone for my IBD?

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    Crohn's Disease & Ulcerative Colitis Depression Digestive Health
    I have been on Prednisolone for over 1 year now and can not seem to get off it. as soon as I start to drop my dose I start getting symptoms of a flare. it is quite depressing and I can get very depressed about it at times. is there anything else I can take to replace prednosolone?
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  • Crohn's & Colitis Australia

    For more than 25 years, Crohn’s & Colitis Australia™ (formerly the Australian Crohn’s and Colitis Association) has been making life more liveable for more than … View Profile

    Steroids such as prednisolone are very effective in reducing inflammation when there is a moderate to severe flare of IBD, but without other medication in place to help maintain that response, the gradual reduction in dose will often bring a return of symptoms.   Some form of maintenance medication is usually prescribed simultaneously for this reason, with immunomodulator drugs (e.g. azathioprine, 6-mercaptopurine) often being used, which not only help in reducing the dose and getting off steroids altogether, but also in completely settling the IBD and keeping most patients in remission for much longer periods.   However these immunomodulator drugs can act slowly, so it may necessary to continue with steroids or increase them for a short time until the other drug kicks-in.   If you have not already done so, ensure your treatment is reviewed by a gastroenterologist.

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