There are three main forms of Motor Neurone Disease. These are:
- Amyotrophic Lateral Sclerosis - features include muscle weakness and spasticity
- Progressive Muscular Atrophy - features are weight loss and fasciculation
- Progressive Pseudobulbar Palsy - features are slurred speech, swallowing difficulties and muscle weakness
Onset is gradual. Symptoms are minor initially but in the later stages features include progressive muscle weakness and wasting. The weakness oftern starts in the hands and feet but becomes more generalised leading to loss of function in limbs, breathing, speech and swallowing muscles until patient can be limited in mobility and ability to perform normal activities of daily living.
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