Thanks
From http://www.nice.org.uk/nicemedia/live/12082/42367/42367.pdf
Neuropathic pain is initiated or caused by nervous system damage or dysfunction. Neuropathic pain is difficult to manage because affected people often have a complex history with unclear or diverse causes and comorbidities. Neuropathic conditions include failed back surgery syndrome (FBSS) and complex regional pain syndrome (CRPS). People with FBSS continue to have back and/or leg pain despite anatomically successful lumbar spine surgery. It is not easy to identify a specific cause of neuropathic pain and people with FBSS may experience mixed back and leg pain. CRPS may happen after a harmful event or period of immobilisation (type I) or nerve injury (type II). Pain and increased sensitivity to pain are the most significant symptoms and are present in almost all people with NICE technology appraisal guidance 159 2 CRPS. Other symptoms can include perceived temperature changes, weakness of movement and changes in skin appearance and condition.
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The burning in the leg, if it is neuropathic in origin, would come from a malfunction of the sensory nerve supplying that region of the body. It may come from damage to the nerve from direct or indirect trauma, such as nerve compression in the lumbar spine or from dseases that directly sffect the nerve, such as diabetes or even from alcohol toxicity. It may also be from a dietary deficiency of vitamins (B Group, in particular) It is important to determine the cause of the neuropathic pain, so that it can be addressed.
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to your account or now (it's free).Exercise Physiologist, Physiotherapist
Hi all,
Neuropathic pain relates to pain from dysfunction within the nervous system.
With the burning leg pain you are experiencing, while it may be true neuropathic pain, as Dr Leow mentioned, the nerve dysfunction may be secondary to another problem. A few quick scenarios may exist:
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to your account or now (it's free).Osteopath
Hi everybody,
Neuropathic pain is pain arising from a primary lesion in the somatosensory nervous system. It is usually a combination nerve trunk and dyststhetic pain. Nerve trunk pain reults from hyperecitability of the nervi nervorum in the connective tissues of the nerve sheath and is dull, cramping and thobbing/toothache like pain. The underlying cause is usually compression or trauma which creates ischemia and hypoxia which leads to inflammation and neurogenic inflammation. Once this occurs the whole nerve trunk can be sensitised and patients will ususally describe pain provoked by movement and neurodynaic tests.
Dystesthetic pain is the searing, sharp, burning, skin crawling sensations that arise from direct injury to the axons of the nerves themselves. This creates abnormal impulse generating sites that become hyperexctiable and pain can be provoked on movement, in the presnece of inflammation or it can be sponatneous due to the incresed insertion of ion channels in the regions of damaged axon, partuicularly the regions that are demyelinated. A very important factor here is the dorsal root ganglion that can enhance sensory conduction and be subjected to sympathetic efferent fibre sprouting. This now means adrenaline and noradrenaline can excite the DRG. Weakness and decreased sensation indicates conductive loss due to afferent fibre compression.
These sensations will be described as unfamiliar; this is a very important descriptor. Remenber the brain; central sensitisation can underlie all types of pain.
Cheers Terry.
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Osteopath
Sorry guys as someone has already stated neuropathic pain is as result of a primary leison and/or dysfunction in the somatosensory system. Left dysfunction out before.
Cheers Terry.
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