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Leukaemias are cancers that affect the blood and bone marrow. All leukaemias start in the bone marrow where developing blood cells, usually developing white cells, undergo a malignant change. They multiply in an uncontrolled way and crowd the marrow, affecting its ability to make normal blood cells. Increasing numbers of abnormal cells, called blast cells or leukaemic blasts eventually spill out of the bone marrow and travel around the body in the bloodstream.
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