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Respiratory & Sleep Medicine Physician
Narcolepsy is hereditary. It does run in families. There is one major area on one of the genes which seems to be responsible, but further research is being undertaken to see if this one location will explain all cases.
As there are some forms of overwhelming tiredness and sleepiness, without a clear explanation, similar to but not typical of narcolepsy, it is likely that other genetic locations will be found in time.
However the large majority of people diagnosed with narcolepsy don't have a family history, which means that the genetic abnormality is a spontaneous mutation. It also means that if you're diagnosed with narcolepsy, more likely than not you will not be able to find narcolepsy in your lineage.
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